|
|
|
|
|
| Kayedpoor,Parvin; Mohamadi,Shima; Karimzadeh-Bardei,Latifeh; Nabiuni,Mohammad. |
| Tumor necrosis factor alpha (TNF-a) and interleukin (IL)-6, are prominent mediators of inflammation and have been confirmed to be elevated in at least a subgroup of women with polycystic ovary syndrome (PCOS). In this study, the effects of Silymarin (SLM) on the expression TNF-a, IL-6, CRP and symptoms of PCOS were studied. In this research, PCOS was induced by injection of Estradiol Valerate. PCOS rats were divided into control and experimental groups received intraperitoneal injection SLM extract daily. After syndrome induction, ovaries were collected for histological and immunohistochemical evaluations. Serum IL-6 was detected by the ELISA kit. The results indicated the significant reduction in inflammatory markers and significant changes follicular... |
| Tipo: Journal article |
Palavras-chave: Immunohistochemistry; Inflammation; Silybum Marianum extract. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200054 |
| |
|
|
| Karimzadeh,Latifeh; Nabiuni,Mohammad; Kouchesfehani,Homa Mohseni; Adham,Hamed; Bagheri,Amir; Sheikholeslami,Azar. |
| Background : Polycystic ovarian syndrome (PCOS) is a low-grade inflammatory disease characterized by hyperandrogenemia, hirsutism, chronic anovulation and vascular disorder. Interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are triggered by inflammatory stimuli and lead to angiogenesis and pathogenesis of the ovary. Honeybee venom (HBV) contains an array of biologically active components possessing various pharmaceutical properties. This study was designed to assess the possibility of HBV application as an anti-inflammatory therapeutic agent to suppress levels of the main inflammatory mediators IL-6, COX-2 and VEGF. To induce PCOS, 1 mg of estradiol valerate (EV) per 100 g of body weight was subcutaneously (SC)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polycystic ovarian syndrome; Honeybee venom; Interlukin-6; Cyclooxygenase-2; Vascular endothelial growth factor. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100317 |
| |
|
|
| Shokohi,Rozmehr; Nabiuni,Mohammad; Moghaddam,Parisa; Irian,Saeed; Miyan,Jaleel A.. |
| ABSTRACT Embryonic cerebrospinal fluid (E-CSF) contains many neurotrophic and growth factors, acts as a growth medium for cortical progenitors, and can modulate proliferation and differentiation of neural stem cells. Mesenchymal stem cells (MSCs) are multipotential stem cells that can differentiate into several types of mesenchymal cells as well as nonmesenchymal cells, such as neural cells. In the present study, the effect of E-CSF on proliferation and neural differentiation of bone marrow mesenchymal stem cells (BM-MSCs) was investigated to test whether E-CSF is capable of driving these cells down the neuronal line. To verify the multipotential characteristics of BM-MSCs, the cells were analyzed for their osteogenic and adipogenic potential. Expression... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cerebrospinal fluid; Neural differentiation; Proliferation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100441 |
| |
|
| |
|
|
|
